The key ingredient in most creams and ointments that helps reduce the pain and discomfort of peripheral neuropathy is capsaicin which is the chemical compound that makes hot peppers taste hot. You will realize reduced peripheral neuropathy discomfort by regularly applying capsaicin topically to the skin where your nerve discomfort is occurring. As capsaicin is absorbed through the skin and enters your nerves it depletes a chemical called substance-P which is a chemical used in the transmission of pain and sensation information in the nerve. By depleting substance-P there are fewer successful transmissions of pain through your nerves thus the apparent reduction of the pain and discomfort.  If you turn to using creams and ointments with capsaicin it is vital that you use it regularly in most cases 4 times per day.  You may get an additional burning sensation for a day or two when you first start using it however over time that sensation will fade and your peripheral neuropathy sensations will be diminished.

I use a capsaicin cream everyday and I have found that my peripheral neuropathy discomfort has been reduced by about 30-40% since using it.  A word of warning, besides the burning you may feel for a couple of days, please make sure you only apply the cream to the area where you are having the pain and discomfort.  Applied to other areas may actually produce a burning sensation in those areas that does not go away and your skin may become a little tender as mine did.  I am careful not to only apply it to areas that are feeling the sensations of peripheral neuropathy.

Another common ingredient you may find in a cream or ointment is camphor.  This compound has been around for centuries and it is one of the key ingredients in Vick’s VapoRub.  It is considered an analgesic thus has properties that reduce the sensation of pain.

All in all most people with peripheral neuropathy will realize a level of pain and discomfort reduction by using creams and ointments designed specifically for peripheral neuropathy as long as you are disciplined and use it regularly according to the recommendations.

Kerasal Neuro Cream, 2 Ounce

Pain relieving foot cream. Penetrates quickly to relieve pain on contact. No mess foam applicator. Keeps feet soft and moisturized, resulting in a healthy appearance.

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Neuro-Eze

A fast-acting topical lotion that supports peripheral nerve function.
Contains L-Arginine, an amino acid essential for optimum nerve health.
A quick and effective nutrient delivery system to address numbness, pain and tingling in the feet and hands.

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Dynamint Muscle Balm – 120ml Bottle

Dynamint muscle balm's unique blend of natural oils and mountain spring water from British Columbia is a perfect formula for rapid and deep tissue penetration. As a natural muscle relaxant, it provides calming, cool-warm therapy to help alleviate discomfort - fast - allowing you to get on with your life.
Suitable for all ages, it gets to work on muscles - exactly where it's needed - almost immediately. It's especially useful in cases of over exertion due to competitive sports activity.
Simply apply a small amount of this non-greasy soothing cream and, within seconds, you feel its relaxing, cool-warm sensation in your muscles.

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Penetrex Pain Relief Therapy [2 Oz] :: Breakthrough (Pat. Pend.) for Arthritis, Back Pain, Tennis Elbow, Fibromyalgia, Sciatica, Plantar Fasciitis, Carpal Tunnel, Sore Muscles, Joints & Chronic Pain

Advanced Formulation Penetrex® is The #1 Pain Relief Therapy on Amazon 3 Years running. Recommended for use on its own or as a complimentary application along with braces, splints, gloves, ultrasound treatment, physical therapy, massage, etc.
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PhysAssist Foot Pain Cream

TINGLING & BURNING SENSATIONS
RESTLESS LEGS
NEUROPATHY PAIN CREAM

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Topricin Foot Pain Relief Cream 2 oz

Perfect for common sports injuries such as plantar fasciitis, achilles tendonitis, strains, sprains, leg cramps, and impact injuries and bruising
Offers soothing treatment for swelling and soreness and effectively treats skin conditions of the feet
Made to penetrate the skin much like a moisturizer

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Gold Bond Pain Relieving Foot Cream-4oz (Pack of 4)

Gold Bond Fast Targeted Foot Pain Relieving Cream temporarily relieves minor foot and ankle aches.
7 Penetrating Ingredients - Since Foot Skin is 20x Thicker. Fast Targeted Relief.
Medicated for Fast Targeted Relief.

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Mission Foot Rehab Cream, 3-Ounce Tube

Revitalizing foot moisturizer and dimethicone skin protectant to help relieve chapped, cracked skin--perfect for not just feet but hands & elbows too
Restores cracked heels quickly and refresehes tired feet--enriched with over 20 vitamins, antioxidants and botanicals
Helps to neutralize foot odor

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Frankincense & Myrrh Neuropathy Rubbing Oil with Essential Oils for Pain Relief, 2 Fluid Ounces – 1 Pack

Frankincense and myrrh neuropathy rubbing oil description: temporary pain relief shooting pain. Prickling pain. Tingling pain. Numbness. Homeopathic rubbing oil for the temporary relief of symptoms of neuropathy. Disclaimer these statements have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure, or prevent any disease.

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Topricin Foot Pain Relief Cream 8 oz

Perfect for common sports injuries such as plantar fasciitis, achilles tendonitis, strains, sprains, leg cramps, and impact injuries and bruising
Offers soothing treatment for swelling and soreness and effectively treats skin conditions of the feet
Made to penetrate the skin much like a moisturizer

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Doctor Care Plus Pain Relief Cream with Emu Oil, MSM, Aloe, Vitamin C, 4 oz

1000's of Satisfied, Pain Free Customers - Deep Penetrating, Fast Acting Ultimate Pain Relief Using Only the Purest Refined Emu Oil, Potent Glucosamine, Finest Quality MSM and the Most Advanced Skin Penetrating Formula Known to Relieve Your Pain Fast and Keep Lasting All While Moisturizing Like NO Other
Fastest and Deepest Pain Relief in Our Category - We Took The Best Emu Formula and Made it Better - NOW WITH VITAMIN C, MSM, Glucosamine - Check Our Natural Extract Ingredients and See Why We Rule the "Blue Emus" Then Try It and Feel The Difference.
100% Satisfaction Guarantee - No Risk - Just Pain Relief from Arthritis, Joint Pain, Muscle Pain, Tendonitis, Bursitis, Carpal Tunnel, Plantar Faschiitis,Tennis Elbow, Golf Elbow, Jumpers Knee, Hip - Neck - Back - Shoulder - Lower Back Pain - & Chronic Pain Caused by Injury, Age and Inflammation. We have the solution, if it doesn't work for your pain, send it back and we will refund your money with no questions asked. Ridding the earth of pain one Amazon customer at a time.

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Premium Pain Relief Cream – NERVANA – Best Natural Anti-Inflammatory Topical Pain Reliever Treatment (2 oz)

FAST ACTING: Highly Concentrated & Gets to Work within 5 Minutes. Lasts for Hours.
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